Magnolia Officinalis Bark Extract
What is this known for?
Magnolia has been used in traditional herbal medicine for centuries to support a calm and positive mood, relaxation, immunity, and stress and weight management.
Why are we using it in Power Off?
Function #1: The Honokiol in Magnolia stimulates sleep-promoting neurons in the brain.
Honokiol modulates GABA, which is responsible for stimulating the sleep-promoting area of the brain called the VLPO. Honkiol also increases the activity of GABA-A receptors, which causes an inhibitory effect on neurotransmitters by decreasing the chances for nerve impulses. Both of these mechanisms promotes a calming response in the brain and help shorten the amount of time it takes to fall asleep.
Alexeev M, Grosenbaugh D, Mott D, Fisher J. The natural products magnolol and honokiol are positive allosteric modulators of both synaptic and extra-synaptic GABAA receptors. Neuropharmacology. 2012;62(8):2507-2514. doi:10.1016/j.neuropharm.2012.03.002.
Woodbury A, Yu S, Wei L, García P. Neuro-Modulating Effects of Honokiol: A Review. Frontiers in Neurology. 2013;4. doi:10.3389/fneur.2013.00130.
Function #2: Magnolia may offer neuroprotective effects by reducing free radicals in the brain.
Too much free radical activity can upset functions performed by membranes in the brain. Magnolia has been found to reduce radical oxygen species, and has been studied specifically in the context of decreasing the rate of neuronal cell death in-vitro.
Hoi C, Ho Y, Baum L, Chow A. Neuroprotective effect of honokiol and magnolol, compounds from Magnolia officinalis, on beta-amyloid-induced toxicity in PC12 cells. Phytotherapy Research. 2010;24(10):1538-1542. doi:10.1002/ptr.3178.
Function #3: Magnolia helps modulate acetylcholine, a neurotransmitter that plays a role in attention and memory.
Excessive acetylcholinerase activity leads to an acetylcholine deficiency, which may affect memory. Magnolia Officinalis helps inhibit acetylcholinerase activity.
Lee Y, Yuk D, Kim T et al. Protective effect of the ethanol extract of Magnolia officinalis and 4-O-methylhonokiol on scopolamine-induced memory impairment and the inhibition of acetylcholinesterase activity. Journal of Natural Medicines. 2009;63(3):274-282. doi:10.1007/s11418-009-0330-z.
Woodbury A, Yu S, Wei L, García P. Neuro-Modulating Effects of Honokiol: A Review. Frontiers in Neurology. 2013;4. doi:10.3389/fneur.2013.00130.
Why this form?
Power Off contains a special standardized Magnolia extract that is rich in honokiol.
Can be found in:
Magnolia Bark